Four clinical stages:
- Chronic convalescent
- Chronic recurrent
- Prodromal stage of neurologic and auditory disturbances
- Bilateral posterior uveitis + diffuse granulomatous choroiditis
- Optic disc oedema
- Exudative RD – multifocal and shallow RD
- Retinal +/- choroidal folds
- Patchy hypofluorescence (delayed choroidal filling)
- Early frames – Multiple punctate hyperfluorescent dots at RPE.
- Late frames – hyperfluorescent dots enlarge and stains surrounding SRF (extent of exudative RD) + optic disc hyperfluorescence.
- Alternate hypofluorescent / hyperfluorescent bands – indicate folds.
- Variable degree of choroidal depigmentation
- Sunset glow fundus (loss of choroidal melanocytes)
- Focal RPE atrophy – nummular depigmented round well-defined chorioretinal scars at mid-peripheral.
- Hyperpigmented linear focal lesions – RPE migration/clumping.
- Cutaneous changes – vitiligo, alopeica or poliosis of eyelashes/brows.
- Granulomatous AAU.
- Systemic corticosteroids.
- Immunosuppressive agents
- OCT to monitor response to treatment – SRF / RPE undulations
- Treat complications – cataract, glaucoma, CNV or subretinal fibrosis accordingly.