Sympathetic Ophthalmia


Definition: Bilateral granulomatous panuveitis that occurs after surgery or penetrating injury to the other eye.

90% develop within 1 year.

Incidence of 0.2% after trauma & 0.01% after surgery.

Early treatment – 50% achieved 6/12 VA.

Late complications – secondary glaucoma, chronic maculopathy, phthisis bulbi.


Presentation:

  1. Bilateral AAU with mutton fat KPs (classical)
  2. Dalen-Fuchs nodules – white-yellowish lesions at RPE
  3. Exudative RD / ONH oedema / CNV / vasculitis / choroiditis / vitritis / CMO

Management:

  1. Good history and clinical examination.
  2. Investigative tools – FFA, ICG, OCT, USS
  3. High dose steroids (up to 2mg/kg/day) with gradual tailoring up to 3 months or pulse methylprednisolone (1g/day) for 3 days.
  4. Immunosuppressive therapy – cyclosporine, cyclophosphamide, azathioprine, chlorambucil.
  5. Intravitreal therapy – IVTA
  6. Prophylactic evisceration/enucleation of injured eye within 10 days.

Special note: With current surgical trend (especially VR surgery), any clinical uveitis in fellow eye – to consider this disease.


Differentials:

  1. Vogt-Koyanagi-Harada disease – usually Asian/blacks, no penetrating injury, with common skin and CNS changes and exudative RD and pleoyctosis in CSF.
  2. Sarcoidosis
  3. Syphilis

Reference:


Location Birmingham Midlands Eye Centre 76 Dudley Road Birmingham B18 7QH UK Phone 0121 554 3801 Hours Mr Ch'ng | Vitreoretinal Clinic Sessions: Monday: 8.30am - 12.30pm Wednesday (alternate): 8.30am - 5.00pm Thursday: 8.30am - 12.30pm Friday: 8.30am - 12.30pm | Vitreoretinal Theatre Sessions: Wednesday (alternate): 8.30am - 5.00pm & Friday (emergency cases): 1.30pm - 5.00pm | Eye Casualty Session: Monday 1.00pm - 4.30pm |
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